Old-time San Francisco food and fun lives on at Mayes Oyster House with a modern twist. Mayes, the oldest seafood restaurant in San Francisco is under new ownership. Founded in 1867 by George Mayes, we are continuing a San Francisco tradition with fresh oysters, delicious salads, kobe burgers and generous cocktails. If you like to party, dance music starts after dinner. Mayes Oyster House is Polk Street's premier dance venue.